The pathogenesis of rheumatoid arthritis.

@article{McInnes2011ThePO,
  title={The pathogenesis of rheumatoid arthritis.},
  author={Iain B. McInnes and Georg Schett},
  journal={The New England journal of medicine},
  year={2011},
  volume={365 23},
  pages={
          2205-19
        }
}
The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality. 

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References

SHOWING 1-10 OF 114 REFERENCES
Cytokines in the pathogenesis of rheumatoid arthritis
TLDR
The crucial effector function of cytokines in the immunological processes that are central to the pathogenesis of rheumatoid arthritis are discussed.
Evolving concepts of rheumatoid arthritis
TLDR
Based on the pathogenic mechanisms, specific therapeutic interventions can be designed to suppress synovial inflammation and joint destruction in rheumatoid arthritis.
Even though T-cell-directed trials have been of limited success, is there reason for optimism?
  • G. Panayi
  • Medicine
    Nature Clinical Practice Rheumatology
  • 2006
TLDR
Whether or not the hypothesis that T cells are involved in the pathogenesis of rheumatoid arthritis is true is considered and, if so, why trials so far have not led to an applicable therapy is considered.
Evidence that cytokines play a role in rheumatoid arthritis.
TLDR
This Review discusses the biologic contribution and therapeutic potential of the major cytokine families to RA pathology, focusing on molecules contained within the TNF-alpha, IL-1,IL-6, Il-23, and IL-2 families.
Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis.
TLDR
This review gives an in-depth discussion on the role of Syk signaling in RA, the possibilities of using Syk as a target and also discusses the possible side effects that could be associated with its inhibition.
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.
TLDR
Relation entre risque de pemphigus et DW1eme et DRW6eme, et relation entre susceptibilite a la polyarthrite rhumatoide and un groupe d'epitopes trouves dans les sous-types non DW10 de DR4.
Osteoclasts and Arthritis
  • G. Schett, S. Teitelbaum
  • Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2009
TLDR
Chronic manifestations of Rheumatoid (RA) and psoriatic arthritis, in particular, are joint destructive consequent to chronic inflammation of the synovial membrane and its bone-associated ligaments and tendons.
...
1
2
3
4
5
...