The pathogenesis of pulmonary fibrosis: a moving target.

  title={The pathogenesis of pulmonary fibrosis: a moving target.},
  author={Wim Wuyts and Carlo Agostini and Katerina M. Antoniou and Demosthenes Bouros and Rachel C Chambers and Vincent Cottin and Jim J. J. Egan and Bart M. Lambrecht and Rik Jozef Urbain Lories and Helen Parfrey and Antje Prasse and Carlos Robalo-Cordeiro and Eric Verbeken and Johny A. Verschakelen and Athol U Wells and Geert M. Verleden},
  journal={The European respiratory journal},
  volume={41 5},
Pulmonary fibrosis is the end stage of many diffuse parenchymal lung diseases. It is characterised by excessive matrix formation leading to destruction of the normal lung architecture and finally death. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the delineation of primary pathways has proven to be elusive. In this review susceptibility and injurious agents, such as viruses and gastro-oesophageal reflux, and their probable role in… CONTINUE READING
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