The pathogenesis of primary cicatricial alopecias.

  title={The pathogenesis of primary cicatricial alopecias.},
  author={M Harries and Ralf Paus},
  journal={The American journal of pathology},
  volume={177 5},
Cicatricial (scarring) alopecia results from irreversible damage to epithelial stem cells located in the bulge region of the hair follicle, generally as a result of inflammatory mechanisms (eg, in the context of autoimmune disease). In primary cicactricial alopecia (PCA), the hair follicle itself is the key target of autoaggressive immunity. This group of permanent hair loss disorders can be classified into distinct subgroups, characterized by the predominant peri-follicular inflammatory cell… CONTINUE READING

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