The pathogenesis of oral lichen planus.

  title={The pathogenesis of oral lichen planus.},
  author={Philip B Sugerman and Neil William Savage and Laurence James Walsh and Zhan Zheng Zhao and Xijing J Zhou and Anver Khan and Gregory John Seymour and Michael E Bigby},
  journal={Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists},
  volume={13 4},
Both antigen-specific and non-specific mechanisms may be involved in the pathogenesis of oral lichen planus (OLP). Antigen-specific mechanisms in OLP include antigen presentation by basal keratinocytes and antigen-specific keratinocyte killing by CD8(+) cytotoxic T-cells. Non-specific mechanisms include mast cell degranulation and matrix metalloproteinase (MMP) activation in OLP lesions. These mechanisms may combine to cause T-cell accumulation in the superficial lamina propria, basement… CONTINUE READING
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