The pathogenesis of neuropsychiatric lupus.


Neuropsychiatric lupus is a frequent and serious complication of systemic lupus erythematosus. Although its pathogenesis has not been fully elucidated several mechanisms based on findings in animals and humans have been proposed: cerebral vasculitis; the cross-reaction of lymphocytotoxic antibodies with brain tissue; choroid plexus dysfunction; and the blocking of neurotransmission by noncytotoxic antibodies. Any or all of these mechanisms may be active in a particular patient at a given time.

Cite this paper

@article{Denburg1983ThePO, title={The pathogenesis of neuropsychiatric lupus.}, author={Judah A. Denburg and Peter I. Temesvari}, journal={Canadian Medical Association journal}, year={1983}, volume={128 3}, pages={257-60} }