The pathogenesis of neural injury in animal models of the antiphospholipid syndrome.


Circulating antiphospholipid antibodies (aPL) are associated with central nervous system dysfunction in antiphospholipid syndrome (APS) patients and in a mouse model of APS. We propose a logical pathway of how experimental APS (eAPS) causes brain dysfunction: binding of the antibodies to the brain endothelium evoking microthrombosis, endothelial dysfunction… (More)
DOI: 10.1007/s12016-009-8154-x

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