The pathogenesis of neural injury in animal models of the antiphospholipid syndrome.

Abstract

Circulating antiphospholipid antibodies (aPL) are associated with central nervous system dysfunction in antiphospholipid syndrome (APS) patients and in a mouse model of APS. We propose a logical pathway of how experimental APS (eAPS) causes brain dysfunction: binding of the antibodies to the brain endothelium evoking microthrombosis, endothelial dysfunction… (More)
DOI: 10.1007/s12016-009-8154-x

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