The pathogenesis of mixed-lineage leukemia.

  title={The pathogenesis of mixed-lineage leukemia.},
  author={Andrew G. Muntean and Jay L. Hess},
  journal={Annual review of pathology},
Aggressive leukemias arise in both children and adults as a result of rearrangements to the mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large histone methyltransferase that directly binds DNA and positively regulates gene transcription, including homeobox (HOX) genes. MLL is involved in chromosomal translocations, partial tandem duplications, and amplifications, all of which result in hematopoietic malignancies due to sustained HOX expression and stalled… CONTINUE READING
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