The pathogenesis of hypophyseal fibrosis in aging: its relationship to tissue iron deposition.


An investigation was made of 101 hypophyses from male and female human subjects dying from unrelated diseases. Careful microscopic examination revealed that fibrous replacement of the gland begins after the fourth decade. There is a gradual increase in iron deposition in this connective tissue after the 4th decade. It is suggested that the fibrous… (More)


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