The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity.

@article{Hayley2005ThePO,
  title={The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity.},
  author={Shawn P Hayley and Michael O Poulter and Zul Merali and Hymie Anisman},
  journal={Neuroscience},
  year={2005},
  volume={135 3},
  pages={659-78}
}
Stressful events promote neurochemical changes that may be involved in the provocation of depressive disorder. In addition to neuroendocrine substrates (e.g. corticotropin releasing hormone, and corticoids) and central neurotransmitters (serotonin and GABA), alterations of neuronal plasticity or even neuronal survival may play a role in depression. Indeed, depression and chronic stressor exposure typically reduce levels of growth factors, including brain-derived neurotrophic factor and anti… CONTINUE READING
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