The pathogenesis of cardiac fibrosis

@article{Kong2013ThePO,
  title={The pathogenesis of cardiac fibrosis},
  author={Ping Kong and Panagiota Christia and Nikolaos G Frangogiannis},
  journal={Cellular and Molecular Life Sciences},
  year={2013},
  volume={71},
  pages={549-574}
}
Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. This review discusses the cellular effectors and molecular pathways implicated in the pathogenesis of cardiac fibrosis. Although activated myofibroblasts are the main effector cells in the fibrotic heart, monocytes/macrophages, lymphocytes, mast cells, vascular cells and… CONTINUE READING
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