The pathogenesis of cancer metastasis

@article{Poste1980ThePO,
  title={The pathogenesis of cancer metastasis},
  author={George H Poste and Isaiah J. Fidler},
  journal={Nature},
  year={1980},
  volume={283},
  pages={139-146}
}
Metastases do not result from random survival of cells released from the primary tumour but from the selective growth of specialised subpopulations of highly metastatic cells endowed with specific properties that befit them to complete each step of the metastatic process. 
Mechanisms of cancer metastasis.
TLDR
Despite significant advances in early diagnosis, general patient care, surgical resection of primary neoplasms, and adjuvant systemic therapies, the majority of patients die from metastatic tumors that are resistant to therapy.
The biologic diversity of cancer metastases.
TLDR
The cellular diversity of primary tumors is now known to be associated with their metastatic potential and Phenomena underlying these pathologic mechanisms and their implications for the development of therapeutic approaches are discussed.
Circumvention of Neoplastic Heterogeneity by Systemically Activated Macrophages
TLDR
The successful therapy of disseminated metastases will have to circumvent the problems of cancer heterogeneity and the development of tumor cell resistance to therapy.
Dedifferentiation in the metastatic progression of prostate carcinoma
TLDR
Detailed histologic analysis of primary prostate carcinoma and synchronous lymph node metastases may improve the understanding of the complex process of cancer progression and metastasis.
Why do cells metastasize?
TLDR
Tumor cells become metastatic after completing a series of sequential steps that require specialization that involves phenotypic changes in tumor cells that occur with tumor growth.
Differentiation and neoplasia. Invasion and metastasis; experimental systems
  • S. Eccles
  • Medicine
    The Journal of pathology
  • 1983
In a series of six transplantable mammary carcinomas and 11 squamous cell carcinomas of mice, evidence of tumour “progression” was obtained in the majority.
The biology of melanoma metastasis.
  • I. Fidler
  • Medicine
    The Journal of dermatologic surgery and oncology
  • 1988
TLDR
A selective biological process is regulated by the interaction of tumor cells with their host, and these complex interactions can now be studied and manipulated.
The organ microenvironment and cancer metastasis.
  • I. Fidler
  • Biology
    Differentiation; research in biological diversity
  • 2002
TLDR
Therapy of metastasis should be targeted not only against tumor cells, but also against the host factors that contribute to and support the progressive growth and survival of metastatic cancer cells.
FROM THE BIOLOGY OF METASTASIS LABORATORY, IMPERIAL CANCER RESEARCH FUND, LINCOLN'S INN
TLDR
The relationship of angiogenesis, the growth of new blood vessels, to the process of tumour metastasis is examined and novel approaches to antimetastatic therapy, using the newly formed vascular bed of tumours as the target, are produced.
Metastasis and angiogenesis.
TLDR
The relationship of angiogenesis, the growth of new blood vessels, to the process of tumour metastasis is examined and novel approaches to antimetastatic therapy, using the newly formed vascular bed of tumours as the target, are produced.
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TLDR
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TLDR
The possible existence of highly metastatic variant cells within a primary tumor suggests that the authors no longer should consider a neoplasm to be a uniform entity and efforts to design effective therapeutic agents and procedures against malignant tumors should be directed toward the few but fatal metastatic subpopulations of cells.
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TLDR
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TLDR
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TLDR
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