The pathogenesis of atherosclerosis: a perspective for the 1990s

@article{Ross1993ThePO,
  title={The pathogenesis of atherosclerosis: a perspective for the 1990s},
  author={R. Ross},
  journal={Nature},
  year={1993},
  volume={362},
  pages={801-809}
}
  • R. Ross
  • Published 1993
  • Medicine
  • Nature
Atherosclerosis, the principal cause of heart attack, stroke and gangrene of the extremities, is responsible for 50% of all mortality in the USA, Europe and Japan. The lesions result from an excessive, inflammatory-fibroproliferative response to various forms of insult to the endothelium and smooth muscle of the artery wall. A large number of growth factors, cytokines and vasoregulatory molecules participate in this process. Our ability to control the expression of genes encoding these… Expand
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