The pathogenesis and progression of the pathological changes of Alzheimer's disease.

Abstract

In this paper, it is argued that the earliest morphological changes of Alzheimer's disease involve the formation of the senile plaque. Key molecular events in this process implicate a deposition of amyloid (A4) protein and an accumulation of an oligosaccharide. These 'preplaques' do not contain neurites, and may first appear in the hippocampus and amygdala… (More)

Topics

Cite this paper

@article{Mann1989ThePA, title={The pathogenesis and progression of the pathological changes of Alzheimer's disease.}, author={David M.A. Mann}, journal={Annals of medicine}, year={1989}, volume={21 2}, pages={133-6} }