The pathogenesis and clinical patterns of blastic crisis of chronic myeloid leukemia.


Blast crisis terminates the life of the majority (approximately 80%) of patients with CML. The time of its onset appears to be a random phenomenon, varying from a probable coincidence occurrence with the onset of CML to more than a decade after onset of the chronic phase. In most patients the diagnosis is obvious as very immature cells are found to be the… (More)


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