The pathobiology of bronchial asthma.

  title={The pathobiology of bronchial asthma.},
  author={Jonathan P. Arm and Tak Hong Lee},
  journal={Advances in immunology},
Early studies of patients dying from status asthmaticus revealed marked inflammation of the bronchial tree. Subsequent histological studies of the airways and examination of bronchoalveolar lavage fluid of subjects with mild asthma have confirmed the presence of airway inflammation in life. There is epithelial edema and desquamation, subepithelial deposition of collagen and fibronectin, and an inflammatory cell infiltrate in the mucosa. There are increased numbers of activated eosinophils, CD25… CONTINUE READING