The parvovirus capsid odyssey: from the cell surface to the nucleus.


During cellular entry and infection, the parvovirus capsid follows a complex path from the cell surface to the nucleus, where the DNA is replicated. Various receptors have been characterized that bind to different parvoviruses and mediate their entry into cells. However, the subsequent trafficking pathways within the endosomal system, cytoplasm and into the nucleus are still not well defined. Studies of viruses entering various cell types under different conditions show particles located in many different endosomal compartments, within the cytoplasm and in the nucleus with significant variations in timing and distribution. Here, we define the previously unresolved issues that are now better understood for the infection pathways of these viruses, and outline some of the areas that remain to be clarified in future studies.

DOI: 10.1016/j.tim.2008.01.012
Citations per Year

183 Citations

Semantic Scholar estimates that this publication has 183 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Harbison2008ThePC, title={The parvovirus capsid odyssey: from the cell surface to the nucleus.}, author={Carole E. Harbison and John A. Chiorini and Colin R Parrish}, journal={Trends in microbiology}, year={2008}, volume={16 5}, pages={208-14} }