The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress.

@article{Aguilera2008ThePV,
  title={The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress.},
  author={G. Romero Aguilera and Sivan Subburaju and Sharla F. Young and Jun Chen},
  journal={Progress in brain research},
  year={2008},
  volume={170},
  pages={29-39}
}
Vasopressin (VP) secreted from parvocellular neurons of the hypothalamic paraventricular nucleus (PVN) stimulates pituitary adrenocorticotropic hormone (ACTH) secretion, through interaction with receptors of the V1b subtype (V1bR) in the pituitary corticotroph, mainly by potentiating the stimulatory effects of corticotrophin-releasing hormone (CRH). Chronic stress paradigms associated with corticotroph hyperresponsiveness lead to preferential expression of hypothalamic VP over CRH and… CONTINUE READING
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