The partial 5-HT1A receptor agonist buspirone enhances neurogenesis in the opossum (Monodelphis domestica)

@article{Grabiec2009TheP5,
  title={The partial 5-HT1A receptor agonist buspirone enhances neurogenesis in the opossum (Monodelphis domestica)},
  author={Marta Grabiec and Kris Turlejski and Rouzanna L. Djavadian},
  journal={European Neuropsychopharmacology},
  year={2009},
  volume={19},
  pages={431-439}
}
We demonstrate for the first time that neurogenesis in the adult Monodelphis opossum has a typical mammalian pattern and occurs only in the dentate gyrus (DG) and subventricular zone (SVZ) of the lateral ventricles. In these two brain regions neurogenesis is present throughout the lifespan, although its rate is reduced by half in the old age. Treatment with buspirone, a partial 5-HT1A receptor agonist which is used in human clinic as an anxiolytic agent, boosts proliferation in the SVZ and DG… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

G-protein-coupled receptors in adult neurogenesis.

  • Pharmacological reviews
  • 2012
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Adult hippocampal neurogenesis in natural populations of mammals.

  • Cold Spring Harbor perspectives in biology
  • 2008
VIEW 10 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED