The parkinsonian toxin MPTP: action and mechanism.

  title={The parkinsonian toxin MPTP: action and mechanism.},
  author={Serge E. Przedborski and Vernice R. Jackson-Lewis and Ruth Djaldetti and Gabriel T. Liberatore and Miquel Vila and Slobodanka Vukosavi{\'c} and Gabrielle Almer},
  journal={Restorative neurology and neuroscience},
  volume={16 2},
MPTP causes damage to substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons as seen in Parkinson's disease (PD). After sys-temic administration of MPTP, its active metabolite, MPP +, accumulates within SNpc DA neurons, where it inhibits ATP production and stim-ulates superoxide radical formation. The produced superoxide radicals react with nitric oxide (NO) to produce peroxynitrite, a highly reactive tissue-damaging species that damages proteins by oxidation and nitration. Only… CONTINUE READING
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