The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1).

@article{Saini2011ThePM,
  title={The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1).},
  author={Nidhi Saini and Oleg G. Georgiev and Walter Schaffner},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 10},
  pages={2151-61}
}
The gene for Parkin, an E3 ubiquitin ligase, is mutated in some familial forms of Parkinson's disease, a severe neurodegenerative disorder. A homozygous mutant of the Drosophila ortholog of human parkin is viable but results in severe motoric impairment including an inability to fly, female and male sterility, and a decreased life span. We show here that a double mutant of the genes for Parkin and the metal-responsive transcription factor 1 (MTF-1) is not viable. MTF-1, which is conserved from… CONTINUE READING