The parathyroid is a target organ for FGF23 in rats.

  title={The parathyroid is a target organ for FGF23 in rats.},
  author={Iddo Z. Ben-Dov and Hillel Galitzer and Vardit Lavi-Moshayoff and Regina Goetz and Makoto Kuro-O and Moosa Mohammadi and Roy Sirkis and Tally Naveh-Many and Justin Silver},
  journal={The Journal of clinical investigation},
  volume={117 12},
Phosphate homeostasis is maintained by a counterbalance between efflux from the kidney and influx from intestine and bone. FGF23 is a bone-derived phosphaturic hormone that acts on the kidney to increase phosphate excretion and suppress biosynthesis of vitamin D. FGF23 signals with highest efficacy through several FGF receptors (FGFRs) bound by the transmembrane protein Klotho as a coreceptor. Since most tissues express FGFR, expression of Klotho determines FGF23 target organs. Here we identify… CONTINUE READING
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