The paraoxonase-1 codon 192 polymorphism is associated with fasting total cholesterol and LDL-cholesterol concentrations only in postmenopausal women. The REGICOR study.

@article{Sent2002ThePC,
  title={The paraoxonase-1 codon 192 polymorphism is associated with fasting total cholesterol and LDL-cholesterol concentrations only in postmenopausal women. The REGICOR study.},
  author={Mariano Sent{\'i} and Marta Tom{\'a}s and Roberto Elosual and Joan Sala and Rafel Masi{\'a} and Jaume Marrugat},
  journal={Clinical chemistry and laboratory medicine},
  year={2002},
  volume={40 7},
  pages={677-83}
}
Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-linked enzyme which appears to protect low-density lipoproteins (LDL) from oxidation. PON1 activity is associated with variation at the PON1 gene locus, specifically the common amino acid polymorphism at codon 192, for which the Q192 allele specifies low activity and the R192 allele specifies high… CONTINUE READING