The paranodal complex of F3/contactin and caspr/paranodin traffics to the cell surface via a non-conventional pathway.

@article{Bonnon2003ThePC,
  title={The paranodal complex of F3/contactin and caspr/paranodin traffics to the cell surface via a non-conventional pathway.},
  author={Carine Gaiser Bonnon and Laurence Goutebroze and Natasha Denisenko-Nehrbass and Jean-Antoine Girault and Catherine Faivre-Sarrailh},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 48},
  pages={48339-47}
}
During myelination, membrane-specialized domains are generated by complex interactions between axon and glial cells. The cell adhesion molecules caspr/paranodin and F3/contactin play a crucial role in the generation of functional septate-like junctions at paranodes. We have previously demonstrated that association with the glycosylphosphatidylinositol-linked F3/contactin is required for the recruitment of caspr/paranodin into the lipid rafts and its targeting to the cell surface. When… CONTINUE READING