The paralysis associated with myelomeningocele: clinical and experimental data implicating a preventable spinal cord injury.

@article{Heffez1990ThePA,
  title={The paralysis associated with myelomeningocele: clinical and experimental data implicating a preventable spinal cord injury.},
  author={Dan S. Heffez and John J Aryanpur and Grover M. Hutchins and J. M. Freeman},
  journal={Neurosurgery},
  year={1990},
  volume={26 6},
  pages={
          987-92
        }
}
Paralysis seen in children with myelomeningocele has been attributed to congenital myelodysplasia. We suspected that paralysis may be due in part to a spinal cord injury caused by exposure of the neural tube to the amniotic fluid. This hypothesis was tested using a fetal rat model of surgically created dysraphism. Each pup from the experimental group of rats in which the spinal cord was intentionally exposed to the amniotic fluid was born with severe deformity and weakness of the hind limbs and… CONTINUE READING
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