The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases.

@article{Cane1999ThePA,
  title={The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases.},
  author={David E Cane and Christopher T Walsh},
  journal={Chemistry & biology},
  year={1999},
  volume={6 12},
  pages={R319-25}
}
Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products. PKS and NRPS proteins share striking architectural and organizational similarities that can be exploited to generate entirely new natural products. 

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