The paradoxical effect of bevacizumab in the therapy of malignant gliomas.

@article{Thompson2011ThePE,
  title={The paradoxical effect of bevacizumab in the therapy of malignant gliomas.},
  author={Eric M Thompson and Eugene P. Frenkel and Edward A Neuwelt},
  journal={Neurology},
  year={2011},
  volume={76 1},
  pages={87-93}
}
One rationale behind the use of agents that inhibit vascular endothelial growth factor in the therapy of primary CNS malignancies is based upon the concept that normalization of tumor vasculature with a decrease in tumor interstitial pressure will improve access of cytoreductive drugs and improve radiotherapy efficacy due to increased oxygen delivery. However, several studies have raised the concern that these agents may both rapidly restore the low permeability characteristics of the blood… CONTINUE READING
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