The paradox of the unfolded protein response in cancer.

  title={The paradox of the unfolded protein response in cancer.},
  author={Yves-Paul Vandewynckel and Debby Laukens and Anja Geerts and Eliene Bogaerts and Annelies Paridaens and Xavier Verhelst and Sophie Janssens and Femke Heindryckx and Hans van Vlierberghe},
  journal={Anticancer research},
  volume={33 11},
The endoplasmic reticulum (ER) is an elaborate organelle that is essential for cellular function and survival. Conditions that interfere with ER functioning can lead to the accumulation of unfolded proteins, which are detected by transmembrane sensors that then initiate the unfolded protein response (UPR) to restore ER proteostasis. If the adaptive response fails, apoptotic cell death ensues. Many studies have focused on how this failure initiates apoptosis, particularly because ER stress… CONTINUE READING
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ATF 4 orchestrates a program of BH 3only protein expression in severe hypoxia

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