The paradox of the renin-angiotensin system in chronic renal disease.

@article{Rosenberg1994ThePO,
  title={The paradox of the renin-angiotensin system in chronic renal disease.},
  author={Mark E. Rosenberg and Lisa M. J. Smith and Ricardo Correa-Rotter and Thomas H. Hostetter},
  journal={Kidney international},
  year={1994},
  volume={45 2},
  pages={
          403-10
        }
}
Despite normal to suppressed levels of renin activity in chronic renal disease, multiple lines of evidence suggest a role for the RAS, especially its intrarenal expression, in several critical aspects of this condition. Alterations in the distribution and control of components of the renal RAS could account for localized areas of activation of this system. Renal scarring may be particularly important as a major stimulus to renin synthesis in the diseased kidney. While both intrarenal and… CONTINUE READING
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