The paradox of smooth muscle physiology.

  title={The paradox of smooth muscle physiology.},
  author={David A Woodrum and Colleen Marie Brophy},
  journal={Molecular and cellular endocrinology},
  volume={177 1-2},
Vascular smooth muscle tone is controlled by a balance between the cellular signaling pathways that mediate the generation of force (contraction) and the release of force (relaxation). The signaling events that activate contraction include Ca(2+)-dependent myosin light chain phosphorylation. The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a… CONTINUE READING


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