The paradox of MHC-DRB exon/intron evolution: alpha-helix and beta-sheet encoding regions diverge while hypervariable intronic simple repeats coevolve with beta-sheet codons.

@article{Schwaiger1993ThePO,
  title={The paradox of MHC-DRB exon/intron evolution: alpha-helix and beta-sheet encoding regions diverge while hypervariable intronic simple repeats coevolve with beta-sheet codons.},
  author={Fabian Schwaiger and E Weyers and Cornelia Epplen and J{\"o}rg Br{\"u}n and Gabi Ruff and Allan Crawford and J{\"o}rg T. Epplen},
  journal={Journal of molecular evolution},
  year={1993},
  volume={37 3},
  pages={260-72}
}
Twenty-one different caprine and 13 ovine MHC-DRB exon 2 sequences were determined including part of the adjacent introns containing simple repetitive (gt)n(ga)m elements. The positions for highly polymorphic DRB amino acids vary slightly among ungulates and other mammals. From man and mouse to ungulates the basic (gt)n(ga)m structure is fixed in evolution for 7 x 10(7) years whereas ample variations exist in the tandem (gt)n and (ga)m dinucleotides and especially their "degenerated… CONTINUE READING
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