The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling.

Abstract

Antigen-receptor-mediated activation of lymphocytes relies on a signalosome comprising CARMA1 (also known as CARD11), BCL10 and MALT1 (the CBM complex). The CBM activates nuclear factor κB (NF-κB) transcription factors by recruiting the 'linear ubiquitin assembly complex' (LUBAC), and unleashes MALT1 paracaspase activity. Although MALT1 enzyme shapes NF-κB… (More)
DOI: 10.1242/jcs.185025

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