The panic-inducing properties of the cholecystokinin tetrapeptide CCK4 in patients with panic disorder.

@article{Megen1996ThePP,
  title={The panic-inducing properties of the cholecystokinin tetrapeptide CCK4 in patients with panic disorder.},
  author={Harold J G M van Megen and Herman G. M. Westenberg and Johannes A den Boer and Ren{\'e} S. Kahn},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={1996},
  volume={6 3},
  pages={187-94}
}
We studied the effect of the cholecystokinin tetrapeptide (CCK4), a potent CCKB antagonist, in patients with panic disorder. Two different dosages (25 and 50 micrograms) of CCK4 and saline were tested in 12 patients who were randomly allocated to 2 of the 3 possible treatment groups. Patients were tested on 2 separate occasions, 1 week apart, using an unbalanced single-blind incomplete block design. A total of 24 intravenous injections were carried out. The panic rate with 25 micrograms CCK was… CONTINUE READING

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