The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis.

@article{FalcnPrez2002TheP,
  title={The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis.},
  author={Juan Manuel Falc{\'o}n-P{\'e}rez and Esteban C Dell'angelica},
  journal={Pigment cell research},
  year={2002},
  volume={15 2},
  pages={82-6}
}
This review focuses on the product of the pallidin (Pldn) gene, one of a number of genes that in mice are associated with pigmentation defects and platelet dense granule deficiency. A similar combination of defects is also observed in patients suffering from Hermansky-Pudlak (HPS) and Chediak-Higashi (CHS) syndromes. Pldn encodes a novel, approximately 20-kDa protein that is expressed ubiquitously in mammalian tissues. The pallidin protein was found to bind to syntaxin 13, a member of the… CONTINUE READING