The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells

@article{Marotta2014ThePB,
  title={The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells},
  author={Pina Marotta and Elena Amendola and Marzia Scarf{\`o} and Pasquale De Luca and Roberto Di Lauro},
  journal={Molecular and Cellular Endocrinology},
  year={2014},
  volume={396},
  pages={26-36}
}
The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypothyroidism, consequent to a reduced gland size and a deranged differentiation. These results demonstrate that Pax8 is also an essential player in controlling survival and… CONTINUE READING

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