The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case.

@article{Cazzaniga2001ThePB,
  title={The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case.},
  author={Giovanni Cazzaniga and Maria Daniotti and Sabrina Tosi and Giovanni Giudici and Alessandra Aloisi and Enrico Maria Pogliani and Lyndal Kearney and Andrea Biondi},
  journal={Cancer research},
  year={2001},
  volume={61 12},
  pages={4666-70}
}
The PAX5 gene, encoding the B-cell-specific activator protein, is a critical determinant of commitment to the B-lymphocyte pathway. This gene, mapped at 9p13, is juxtaposed to the immunoglobulin heavy chain (IgH) gene as a result of the t(9;14)(p13;q32), a rare but recurring translocation found in a subset of B-cell non-Hodgkin's lymphoma cases. In all of these, this translocation results in deregulated expression of the gene product because of the proximity of IgH. We present here the… CONTINUE READING
58 Citations
23 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

The role of chimeric paired box transcription factors in the pathogenesis of pediatric rhabdomyosarcoma

  • F. G. Barr
  • Cancer Res.,
  • 1999
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…