The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2).

@article{Kara2014ThePB,
  title={The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2).},
  author={Im{\`e}ne Kara and Marjorie Poggi and Bernadette Bonardo and Roland Govers and Jean-François Landrier and Shiyong Tian and Ingo B. Leibiger and Robert Day and John W Creemers and Franck Peiretti},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={290 5},
  pages={
          2812-21
        }
}
Gaining the full activity of the insulin receptor (IR) requires the proteolytic cleavage of its proform by intra-Golgi furin-like activity. In mammalian cells, IR is expressed as two isoforms (IRB and IRA) that are responsible for insulin action. However, only IRA transmits the growth-promoting and mitogenic effects of insulin-like growth factor 2. Here we demonstrate that the two IR isoforms are similarly cleaved by furin, but when this furin-dependent maturation is inefficient, IR proforms… CONTINUE READING

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