The pain receptor TRPV1 displays agonist-dependent activation stoichiometry

  title={The pain receptor TRPV1 displays agonist-dependent activation stoichiometry},
  author={Adina Hazan and Rakesh Kumar and Henry Matzner and Avi Priel},
  booktitle={Scientific reports},
The receptor channel TRPV1 (Transient Receptor Potential Vanilloid 1) is expressed by primary afferent sensory neurons of the pain pathway, where it functions as a sensor of noxious heat and various chemicals, including eicosanoids, capsaicin, protons and peptide toxins. Comprised of four identical subunits that organize into a non-selective cationic permeable channel, this receptor has a variety of binding sites responsible for detecting their respective agonists. Although its physiological… CONTINUE READING
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