The pace and proliferation of biological technologies.

@article{Carlson2003ThePA,
  title={The pace and proliferation of biological technologies.},
  author={Robert Carlson},
  journal={Biosecurity and bioterrorism : biodefense strategy, practice, and science},
  year={2003},
  volume={1 3},
  pages={
          203-14
        }
}
  • Robert Carlson
  • Published 2003
  • Business, Medicine
  • Biosecurity and bioterrorism : biodefense strategy, practice, and science
THE ADVENT OF THE home molecular biology laboratory is not far off. While there is no Star Trek “Tricorder” in sight, the physical infrastructure of molecular biology is becoming more sophisticated and less expensive every day. Automated commercial instrumentation handles an increasing fraction of laboratory tasks that were once the sole province of doctoral level researchers, reducing labor costs and increasing productivity. This technology is gradually moving into the broader marketplace as… Expand
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References

SHOWING 1-10 OF 32 REFERENCES
Sequence information can be obtained from single DNA molecules
TLDR
These experiments show that one can study the activity of DNA polymerase at the single molecule level with single base resolution and a high degree of parallelization, thus providing the foundation for a practical single molecule sequencing technology. Expand
Pyrosequencing sheds light on DNA sequencing.
TLDR
Key features regarding different aspects of pyrosequencing technology are considered, including the general principles, enzyme properties, sequencing modes, instrumentation, and potential applications. Expand
Computational design of receptor and sensor proteins with novel functions
TLDR
A structure-based computational method was used to construct soluble receptors that bind trinitrotoluene, l-lactate or serotonin with high selectivity and affinity, and these engineered receptors can function as biosensors for their new ligands. Expand
Genetic engineering using homologous recombination.
TLDR
This review describes not only recombineering and its applications, but also summarizes homologous recombination in E. coli and early uses of homologously recombination to modify the bacterial chromosome. Expand
Cramming More Components Onto Integrated Circuits
  • G. Moore
  • Computer Science, Engineering
  • Proceedings of the IEEE
  • 1998
The future of integrated electronics is the future of electronics itself. The advantages of integration will bring about a proliferation of electronics, pushing this science into many new areas.Expand
Uptake and processing of DNA by Acinetobacter calcoaceticus--a review.
TLDR
Analysis of DNA translocation in Acinetobacter calcoaceticus, a Gram-negative eubacterium that is able to migrate through twitching motility, and also shows a high frequency of natural transformation, finds no components, common to the translocation of macromolecules through the cell envelope of AcinetOBacter, have been detected in this screen. Expand
Mutational Analysis of the Critical Bases Involved in Activation of the AreR-Regulated σ54-Dependent Promoter in Acinetobacter sp. Strain ADP1
TLDR
A method for site-directed mutagenesis of chromosomal genes inADP1 is reported here in which linear fragments generated by overlap extension PCR are used to transform ADP1 via its natural transformation system and recombinants are selected by a marker exchange-eviction strategy with a newly created sacB-Km cassette. Expand
The genome sequence of the plant pathogen Xylella fastidiosa
TLDR
The complete genome sequence of X. fastidiosa clone 9a5c is reported, providing direct evidence of phage-mediated horizontal gene transfer and indicating that the molecular basis for bacterial pathogenicity is both conserved and independent of host. Expand
A new logic for DNA engineering using recombination in Escherichia coli
A straightforward way to engineer DNA in E. coli using homologous recombination is described. The homologous recombination reaction uses RecE and RecT and is transferable between E. coli strains.Expand
Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium.
TLDR
Genome analysis of the Acinetobacter ADP1 revealed genes for metabolic pathways involved in utilization of a large variety of compounds, supporting the view that the cycle itself is centrally geared to the catabolic capabilities of this exceptionally versatile organism. Expand
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