The pH response of rat cutaneous nociceptors correlates with extracellular [Na+] and is increased under amiloride.

@article{Steen1999ThePR,
  title={The pH response of rat cutaneous nociceptors correlates with extracellular [Na+] and is increased under amiloride.},
  author={Kay Hinrich Steen and Holger Wegner and Peter W Reeh},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 8},
  pages={2783-92}
}
Excess hydrogen ions induce sustained nociceptor excitation as well as pain, and this has been suggested, with evidence from sensory ganglion cells, to result from gating a slowly inactivating sodium/calcium inward current. In the rat skin-nerve preparation, isolated receptive fields of pH-sensitive C-fibre terminals were exposed to low-pH solutions of various sodium concentrations. The pH responses showed a good correlation with log [Na+]e, which supports the above model. Amiloride has… CONTINUE READING

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