The pH dependent configurations of the C.A mispair in DNA.

  title={The pH dependent configurations of the C.A mispair in DNA.},
  author={Yves Boulard and Jean A. H. Cognet and Jacques Gabarro-Arpa and Marc Le Bret and Lawrence C. Sowers and G. Victor Fazakerley},
  journal={Nucleic acids research},
  volume={20 8},
The structure of the cytosine-adenine mispair in a 7 base pair duplex has been investigated by proton NMR spectroscopy. At low pH, the predominant structure is protonated on the A residue and assumes a wobble conformation consistent with previous findings. The C residue of the mispair is found in a C2'-C3' endo equilibrium. This is confirmed by molecular dynamics calculations which suggest that the conformation of the protonated wobble is flexible and not as rigid as a normal base pair. As the… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 19 references


C Carbonnaux, G A Van Der Marel, J H Van Boom, W Guschlbauer, G V Fazakerley
Biochemistry • 1991

J. Amer. Chem. Soc

C Wang, H Gao, B L Gaffney, R A Jones
J. Amer. Chem. Soc • 1991

Nucl. Acids Res

Y Boulard, J Gabarro-Arpa, +5 authors W Fazakerley
Nucl. Acids Res • 1991

J. Biomol. Str. Dynam

J A H Cognet, J Gabarro-Arpa, +3 authors Le Bret
J. Biomol. Str. Dynam • 1990

J. Mol. Bid

T Brown, G A Leonard, E D Booth, G Kncale
J. Mol. Bid • 1990


V Sklenar, J Feigon
Nature • 1990

Nature Biochemistry

P Rajagopal, J Feigon
Nature Biochemistry • 1989

J. Am. Chem. Soc

X Gao, D J Patel
J. Am. Chem. Soc • 1988

J. Biol. Chem

L C Sowers, R Eritja, B Kaplan, M F Goodman, G V Fazakeriey
J. Biol. Chem • 1988

Mutat. Res

L C Sowers, B R Shaw, M L Veigl, W D Sedwick
Mutat. Res • 1987

Similar Papers

Loading similar papers…