The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho

@article{Yamashita2002ThePR,
  title={The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho},
  author={Toshihide Yamashita and Haruhisa Higuchi and Masaya Tohyama},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={565 - 570}
}
Myelin-associated glycoprotein (MAG) is a potent inhibitor of neurite outgrowth from a variety of neurons. The receptor for MAG or signals that elicit morphological changes in neurons remained to be established. Here we show that the neurotrophin receptor p75 (p75(NTR)) is the signal transducing element for MAG. Adult dorsal root ganglion neurons or postnatal cerebellar neurons from mice carrying a mutation in the p75(NTR) gene are insensitive to MAG with regard to neurite outgrowth. MAG… CONTINUE READING
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