The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI

@article{Yamashita2003ThePR,
  title={The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI},
  author={Toshihide Yamashita and Masaya Tohyama},
  journal={Nature Neuroscience},
  year={2003},
  volume={6},
  pages={461-467}
}
The neurotrophin receptor p75NTR is involved in the regulation of axonal elongation by neurotrophins as well as several myelin components, including Nogo, myelin-associated glycoprotein (MAG) and myelin oligodendrocyte glycoprotein (OMgp). Neurotrophins stimulate neurite outgrowth by inhibiting Rho activity, whereas myelin-derived proteins activate RhoA and thereby inhibit growth. Here we show that direct interaction of the Rho GDP dissociation inhibitor (Rho-GDI) with p75NTR initiates the… 
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