The p66ShcA adaptor protein regulates healing after myocardial infarction

  title={The p66ShcA adaptor protein regulates healing after myocardial infarction},
  author={Anton Baysa and Julia Sagave and Andrea Carpi and Tania Zaglia and Marika Campesan and Christen Peder Dahl and Dusan Bilbija and Maria Troitskaya and Lars Gullestad and Marco Giorgio and Marco Mongillo and Fabio Di Lisa and Jarle I. Vaage and Guro Valen},
  journal={Basic Research in Cardiology},
Heart rupture and heart failure are deleterious complications of myocardial infarction. The ShcA gene encodes for three protein isoforms, p46-, p52- and p66ShcA. p66ShcA induces oxidative stress. We studied the role of p66ShcA post-infarction. Expression of p66ShcA was analyzed in myocardium of patients with stable angina (n = 11), in explanted hearts with end-stage ischemic heart failure (n = 9) and compared to non-failing hearts not suitable for donation (n = 7). p66ShcA was increased in the… CONTINUE READING
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