The p66Shc Adaptor Protein Controls Oxidative Stress Response in Early Bovine Embryos

@inproceedings{Betts2014ThePA,
  title={The p66Shc Adaptor Protein Controls Oxidative Stress Response in Early Bovine Embryos},
  author={Dean Harvey Betts and Nathan T. Bain and Pavneesh Madan},
  booktitle={PloS one},
  year={2014}
}
The in vitro production of mammalian embryos suffers from high frequencies of developmental failure due to excessive levels of permanent embryo arrest and apoptosis caused by oxidative stress. The p66Shc stress adaptor protein controls oxidative stress response of somatic cells by regulating intracellular ROS levels through multiple pathways, including mitochondrial ROS generation and the repression of antioxidant gene expression. We have previously demonstrated a strong relationship with… CONTINUE READING
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