The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription.

Abstract

Snail1 is a transcriptional repressor of E-cadherin that triggers epithelial-mesenchymal transition (EMT). Here, we report assisted Snail1 interaction with the promoter of a typical mesenchymal gene, fibronectin (FN1), both in epithelial cells undergoing EMT and in fibroblasts. Together with Snail1, the p65 subunit of NF-κB and PARP1 bound to the FN1… (More)
DOI: 10.1242/jcs.078824

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