The p60c-src family of protein-tyrosine kinases: structure, regulation, and function.

@article{Brickell1992ThePF,
  title={The p60c-src family of protein-tyrosine kinases: structure, regulation, and function.},
  author={Paul M. Brickell},
  journal={Critical reviews in oncogenesis},
  year={1992},
  volume={3 4},
  pages={401-46}
}
In 1911, Peyton Rous reported that a fibrosarcoma could be transmitted between chickens in a cell-free extract of the tumor. The transmissible agent, Rous sarcoma virus (RSV), transforms cells by virtue of the presence within its genome of a viral oncogene, v-src, which is derived from a normal cellular gene that has been picked up, or transduced, by the virus. This cellular proto-oncogene, c-src, encodes a protein, p60c-src, which has the ability to phosphorylate proteins on tyrosine residues… CONTINUE READING

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