The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity.

@article{Hill2000ThePT,
  title={The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity.},
  author={Geoffrey R Hill and Takanori Teshima and Vivienne I. Rebel and Oleg I. Krijanovski and Kenneth R. Cooke and Yani S. Brinson and James L. M. Ferrara},
  journal={Journal of immunology},
  year={2000},
  volume={164 2},
  pages={656-63}
}
TNF-alpha is known to be an important mediator of tissue damage during allograft rejection and graft-vs-host disease (GVHD), but its role in supporting T cell responses to allogeneic Ags is unclear. We have studied this question by comparing normal mice with those lacking the p55 (p55 TNFR-/-) or p75 (p75 TNFR-/-) TNF-alpha receptors as donors in well-defined bone marrow transplant (BMT) models. Recipients of p55 TNFR-/- cells had significantly reduced mortality and morbidity from GVHD compared… CONTINUE READING

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