The p53 tumor suppressor targets a novel regulator of G protein signaling.

  title={The p53 tumor suppressor targets a novel regulator of G protein signaling.},
  author={Leonard Buckbinder and Susana Velasco-Miguel and Yan Chen and Nianhua Xu and Randy Talbott and Larry Gelbert and Jianjun Gao and Bernd R. Seizinger and J. Silvio Gutkind and Nikolai Kley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 15},
Heterotrimeric G proteins transduce multiple growth-factor-receptor-initiated and intracellular signals that may lead to activation of the mitogen-activated or stress-activated protein kinases. Herein we report on the identification of a novel p53 target gene (A28-RGS14) that is induced in response to genotoxic stress and encodes a novel member of a family of regulators of G protein signaling (RGS) proteins with proposed GTPase-activating protein activity. Overexpression of A28-RGS14p protein… CONTINUE READING


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Buckbinder et al

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