The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.

@article{Matthew2009ThePT,
  title={The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.},
  author={Elizabeth M. Matthew and Lori S. Hart and Aristotelis Astrinidis and Arunasalam Navaraj and Nathan G. Dolloff and David T. Dicker and Elizabeth P Henske and Wafik S El-Deiry},
  journal={Cell cycle},
  year={2009},
  volume={8 24},
  pages={4168-75}
}
Tuberous sclerosis complex 1 (TSC1) inhibits mammalian target of rapamycin (mTOR), a central promotor of cell growth and proliferation. The protein product of the TSC1 gene, hamartin (referred to as TSC1) is known to interact with Polo-like kinase 1 (Plk1) in a cell cycle regulated, phosphorylation-dependent manner. We hypothesized that the p53 target gene, Plk2, is a tumor suppressor, mediating its tumor suppressor function through interactions with TSC1 that facilitate TSC1/2 restraint of… CONTINUE READING
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