The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

@article{Pant2012ThePP,
  title={The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.},
  author={Vinod Pant and Alfonso Quint{\'a}s-Cardama and Guillermina Lozano},
  journal={Blood},
  year={2012},
  volume={120 26},
  pages={5118-27}
}
Aberrations in the p53 tumor suppressor pathway are associated with hematologic malignancies. p53-dependent cell cycle control, senescence, and apoptosis functions are actively involved in maintaining hematopoietic homeostasis under normal and stress conditions. Whereas loss of p53 function promotes leukemia and lymphoma development in humans and mice, increased p53 activity inhibits hematopoietic stem cell function and results in myelodysplasia. Thus, exquisite regulation of p53 activity is… CONTINUE READING
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